การพัฒนาและประเมินประสิทธิผลของเครื่องมือเฝ้าระวังอาการไม่พึงประสงค์จากยาวัณโรค โรงพยาบาลกันทรวิชัย จังหวัดมหาสารคาม
Abstract
Abstract
Background : Adverse drug reactions (ADRs) from anti-tuberculosis medications are common and contribute to poor medication adherence, leading to drug resistance and increased risk of mortality during treatment. The development of an ADR monitoring tool, utilizing communication technology and theoretical frameworks, can help facilitate early detection and timely intervention.
Objective : To develop and evaluate the effectiveness of a monitoring tool for tracking adverse drug reactions in tuberculosis patients.
Methods: This action research was conducted with 15 tuberculosis patients and 11 healthcare personnel at Kantharawichai Hospital, Mahasarakham Province, during January–June 2024. Focus group discussions with key stakeholders were used to develop the tool. Effectiveness was assessed by pre- and post-intervention tests of staff knowledge and skills, as well as the ability to identify patients experiencing ADRs.
Results : The participatory development process led to an ADR surveillance and monitoring approach suitable for district-level implementation. The developed tool comprised an ADR assessment form, a user manual, and a monitoring system available in both paper-based and online (Google Form) formats. The tool enabled the identification of 13 tuberculosis patients (86.67%) with ADRs, most commonly reddish-orange discoloration of bodily secretions (36.46%). After implementation, healthcare providers' knowledge and skills significantly improved (p < 0.001), with mean scores increasing from 4.46±1.54 to 6.60±1.79 out of 10. User satisfaction was rated as good to excellent (4.38–4.86 out of 5).
Conclusion : The participatory development of an ADR monitoring tool for tuberculosis treatment, combined with modern communication technology, effectively enhanced staff knowledge, skills, and the capacity to detect ADRs. This approach may be adopted in other community hospitals to improve tuberculosis medication safety and reduce mortality during treatment.
Keywords : Adverse drug reaction monitoring, tuberculosis, pharmacovigilance tool, healthcare innovation, TB patient safety
