Subtyping of HIV-1 in Infected Mothers and and Injecting Drug Users During 1994-1995 - การศึกษาชนิดของ Subtype ของเชื้อ HIV-1 ในกลุ่มมารดาที่ติดเชื้อและกลุ่มผู้ติดยาชนิดฉีดเข้าเส้นระหว่างพ. ศ. 2537-2538

Abstract

The percentage of HIV-1 subtype E and subtype B were studied in HIV-1 infected mothers who delivered at Chiang Rai Regional Hospital Center and injecting drug users (IDU) from Thanyarak Narcotics Hospital, Pathumthani, During 1994-1995. The subtypes were analyzed by a peptide binding enzymeimmunoassay (PEIA) using specific synthetic peptides of 14 amino acid derived from V3-loop of gp 120. Of those 111 HIV-1 infected mothers, 109 (89.2%) were infected by HIV-1 subtype E while 2 (1.8%) were infected by HIV-1 subtype B. When 141 IDU were analyzed, 67 (47.5%) were infected by subtype E and 74 (52.5%) were infected by subtype B. These results showed that subtype E was predominant in the mothers who acquired HIV-1 infection via heterosexual transmission. However, in IDU, both subtypes were nearly equal and the percentage of subtype E in this group was slightly higher. Such data may indicated that the distribution of HIV-1 subtype E and subtype B in IDU, now, is near equilibrium. This postulation has to be kept on surveillance and further investigations are needed.