Risk Factors Related to Intracranial Hemorrhage in Ischemic Stroke Patients Undergoing rt-PA Treatment at Chaiyaphum Hospital
Keywords:
Intracranial hemorrhage, ischemic stroke patients, rt-PAAbstract
This study aimed to analyze factors associated with hemorrhagic transformation in ischemic stroke patients who received rt-PA at Chaiyaphum Hospital. This was a cross-sectional analytical study using retrospective data from 370 stroke patients who received rt-PA between 2022 and 2024. Data were analyzed using descriptive statistics and multiple logistic regression.
The study found that the median age of the sample was 69 years (21-92 years), with the majority being male (54.1%). The incidence of hemorrhagic transformation after rt-PA administration was 14.3% (95% CI: 10.9-18.3). Additionally, both systolic and diastolic blood pressure levels significantly decreased after rt-PA administration (p<0.001). Multiple logistic regression analysis revealed that alcohol dependence (OR = 2.99, 95% CI: 1.46-6.10), chronic kidney disease stages 3-5 (OR = 2.27, 95% CI: 1.06-4.86), increasing age (OR = 1.04, 95% CI: 1.01-1.08), and Door-to-Needle time (OR = 1.01, 95% CI: 1.001-1.03) were statistically significantly associated with hemorrhagic transformation after rt-PA administration.
Alcohol dependence, chronic kidney disease stages 3-5, age, and Door-to-Needle time are factors associated with hemorrhagic transformation in ischemic stroke patients receiving rt-PA. Appropriate assessment and management of these factors may help reduce the risk and improve treatment outcomes in this patient group.
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