Effectiveness of Centella asiatica Extract Cream in Reducing Symptoms of Atopic Dermatitis
Keywords:
Centella asiatica, atopic dermatitis, herbAbstract
The aim of this study was to investigate the efficacy of Centella asiatica extract cream in alleviating
diverse symptoms among pediatric patients diagnosed with atopic dermatitis at Chao Phraya Abhaibhubejhr
Hospital. The study employed a double-blind design and included a sample of 40 Thai children ranging
in age from 1 to 17 years. The participants were randomly allocated into two groups: Centella asiatica
extract cream and placebo group. The cream was administered twice daily for a consecutive period
of 28 days. The clinical manifestations including swelling, dryness, oozing/crusting, scratch marks,
lichenification and redness were investigated. The itch severity and sleep quality were assessed by visual
analog scale and the appearance of the skin was also observed at each interval of 7 days. The collected
data were subjected to statistical analysis (Wilcoxon Signed rank test and Mann Whitney U test). The
results revealed that participants who were administered Centella asiatica extract cream exhibited a
significant decrease in severity of the disease (p<0.05). Furthermore, it was observed that the participants
experienced a decrease in loss of sleep and exhibited enhanced clinical results, particularly in relation to
symptoms of swelling. However, there was no significant difference between the two groups. The present
investigation successfully validated the efficacy of utilizing a cream containing Centella asiatica extract
cream in alleviating symptoms and lowering the severity of atopic dermatitis. Our data demonstrated that
Centella asiatica cream could be a potential therapeutic alternative for the treatment of atopic dermatitis.
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